When combining Dr. Tobias Colon 14 Day Cleanse and Dr. Tobias Liver 21 Day Cleanse, we recommend starting with the Colon product. When the cleansing outcome gets less (after 7-8 days) start the Liver Support product. The Colon product needs to be taken at bedtime, so when taking Liver Support in the evening, we recommend doing that around 5-6 pm.